Supermute
Supermute no longer exists, because Twitter has gotten rid of the API that we need for it to work. This is the same API that let third party Twitter clients like TweetBot exist. It sucks. We hope that Supermute made Twitter a little more bearable for a couple years for you.
For posterity's sake, here is the former description of what Supermute did:
Supermute a blunt tool. You can define any phrase you'd like to mute for up to 7 days. During that time period, if anyone in your timeline (including people RTed into your timeline) says that phrase, that account gets muted until the time period is over. Like, their whole account. Capitalization doesn't matter. It'll even pick up partial phrases, so if you mute "horse" you'll also mute people who say "seahorse", or post a link to "http://example.com/horses", and so on. This is useful for muting big conferences/events, avoiding TV spoilers, or just taking a break from certain politicians or topics for an evening.
This uses Twitter's mute function. We keep track here of who you've muted via this tool, so you can check in and see how it's going if you want. We'll never let anyone else know you muted them, promise. We'll also never tweet on your behalf. All we do is mute and unmute. You can even cancel a supermute partway through.